Marc Freeman, PhD: Neurotherapeutics Institute


neuro therapeutic since it was fun by
this group of researchers should get together and such as faculty only we
have a choctaw and uh… in it was nuclear by melissa more
and it’s a pretty wide open discussion and one of the things that they were
great from the from day one is because we have i’m such a diversity
of people who work on things like arnie biology uh… biochemistry myself for this awful
genesis two studies developmental biology max on the generation to be like bob who are real clinicians
are working with the return of patience every time we talk about something you would get such a broad array
perspectives in the discussion that um for example melissa would teach us so
amazing things about our and biology uh… i would turn of tell about how we
could use to that extent answer questions and itself uh… says it was pretty free form and
slides are not allowed the discussions are just fabulous and that went on for uh… probably six months to a year and
then we finally realized after many many people from diverse departments came that we had real strength here inner
degeneration research and uh… you maps and we’ve got fishing for manner of
therapeutic sensitive was really just because they were so many people here
who had a really strong interest in her degeneration but came
out of very different angles and and i think that sort of the strength of the
club is that everybody looks at questions very
differently and two together we can come up with
some really interesting ideas ayam primarily uh… drosophila geneticist
anais are these true flies for the duration of my career have grad school
post-doc and since i started my lab seven years ago and what we status most relevant to com than a thirty since it is the cellular
and molecular ways in which exxon’s destroy themselves so in every narrow degenerative disease if
you look at the patient’s brain or if you look and mouse models order first things you see is or or
other relief agencies is the new generation of acts on the long
protections from neurons and a lot so soon after the way which
they make connections with other cells and uh… what we actually disease the
fruit fly uh… as a model to just cuttack sons and watch that happen and as it turns out ’em when you cut an exxon it was thought
that this sort of wasted away because it it’s not hooked up to his cell body doesn’t have a so-called nutrient supply
but it turns out that’s actually active purple ekkada programs that when you cut
the axe on exxon knows it’s cutting prices on destruction so we do is the actually use the flies
genetics to screen for mutations with black that from happening
so for example we found one newton uh… where we can cut ac sons and
rather than having his exile to generate within a day like they do in a while typing they could actually stay intact for
thirty to fifty days which is longer than most lies live so center for the
duration of lifestyle flight and very recently so we identically
found the newton we clone the gene if the gene is welcome sir from worms the
flies two miles to humans it we just recently attended a that when
you do the same experiment a mouse with the knockout that you can cut the axe
and an axe on will survive after injury said now course the ideas we have this molecule that can suppress
acts on the generation and since you see acts on degeneration
stanislaus and in diseases if we bring any case into a disease
background-color block disease progression we actually a nazi is
involves a lot smiles at him crossed in this mutation see that suppresses
disease on sunday last mice and with dot mil wrote a where do the
same thing with huntington models and so the idea is if you can rescue the axe on
a note and this is an afs maybe or slow disease or stop it for a patient that could mean um… maintenance of function for much
longer than is normal

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