MDTV on Pregnancy and Autoimmune Disease: Preeclampsia



let's learn more about some of the complications of pregnancy and common autoimmune diseases in this mdtv medical moment preeclampsia is one of the most feared complications affecting up to ten percent of all pregnancies worldwide it typically arises after 32 weeks although onset can be earlier preeclampsia is both associated with autoimmune diseases especially systemic lupus erythematosus and it's symptoms tend to mimic those of both disease flares and a pregnancy itself with swelling pitting edema and epigastric pain thus it can be one of the more important differential diagnoses facing the medical team hallmarks of preeclampsia are a rapid rise in blood pressure and protein in the urine these are caused by endothelial dysfunction which itself appears to be triggered by substances in the placenta mechanistically preeclampsia has been traced to a shallowly implanted placenta which becomes hypoxic leading to an immune reaction and secretion of upregulated inflammatory factors all this may or may not reflect mune illogic intolerance in women with autoimmune disease it's a chicken and egg question a positive diagnosis of preeclampsia is reached when systolic blood pressure is higher than 140 millimeters mercury and diastolic pressure higher than 90 millimeters mercury in two separate readings taken six hours apart blood pressure readings are combined with 300 milligrams of protein in a 24-hour urine sample although there can be pregnancy-induced hypertension without proteinuria any rise in systolic pressure of more than 30 points above baseline or a diastolic pressure increase of more than 15 points above baseline is also taken as a warning sign unquestionably the development of preeclampsia can be life-threatening to both mother and fetus the elevated blood pressure poses a cardiovascular risk and there may be generalised damage to the maternal and öthey liam kidneys and liver which also poses fetal wrists with few treatments available preeclampsia poses more risk the longer delivery is delayed the obstetrician will likely prescribe bed rest until the fetus is viable and can be the levert this has been an mdtv medical moment you're watching mdtv we'll be right back

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